Medicine & Health

Illustration of a lung volume reduction surgeryIn many cases of advanced emphysema, reducing the size of the lungs surgically has been shown to improve both survival and quality of life. But some emphysema patients can’t tolerate this bilateral operation. Now a study conducted by researchers at Washington University School of Medicine in St. Louis and the University of Pennsylvania Health System has shown that unilateral, or one-sided, lung volume reduction surgery has significant benefits, offering help to those who are not candidates for the bilateral surgery. More…

Restricting calories may mean living longer.Can eating a low-calorie yet nutritionally balanced diet extend human life as it does in rodents? Preliminary research suggests it might, so researchers at Washington University School of Medicine in St. Louis are launching a long-term study to find out. More…

Islets isolated from a rat pancreasDiabetes researchers hoping to enlist the help of a protein targeted by cancer therapies have gained an important new insight into how the protein, known as mTOR, works in the pancreas. Ironically, diabetes researchers are hoping to promote the capability of mTOR that oncologists want to shut down: its ability to cause cells to reproduce by dividing into copies of themselves. That capacity can be deadly in tumors, but diabetes researchers want to use mTOR’s ability to make cells divide to maintain enough insulin-making beta cells in the pancreas to prevent diabetes. More…

<img src="/news/PublishingImages/4048_t.jpg" alt="Pretty fly — for a fruit fly. The areas stained blue are regions in the fruit fly where the spineless gene is expressed.” height=”211″ width=”150″ />Pretty fly – for a fruit fly. The areas stained blue are regions in the fruit fly where the spineless gene is expressed.A team of researchers that includes biologists from Washington University in St. Louis has discovered that a gene involved in the development and function of the fruit fly antenna also gives the organism its color vision. Claude Desplan, Ph.D., professor of biology at New York University, and his students made the discovery and provided the data. Ian Duncan, Washington University professor of biology, and his wife, research assistant Dianne Duncan, provided the Desplan laboratory fruit fly (Drosophila) clones and mutants and technical assistance that helped locate where the gene, called spineless, is expressed in the retina. More…

Unraveling the mysteries of the human brain, and the mind it gives rise to, is within the reach of modern science, suggests a forthcoming issue of the journal Neuroscience. The special issue explores how sophisticated working memory processes — from the firing of a single neuron to the activation of multiple brain regions — help shape our understanding of the world, says issue co-editor Grega Repovs, a visiting post-doctoral fellow at Washington University in St. Louis. More…

A team of researchers at the School of Medicine is studying how fatty liver disease affects sugar and fat metabolism in overweight adolescents and how losing weight affects the condition. In the last 30 years, the number of overweight children has doubled in the United States, and overweight children are at increased risk for the problem.

Below is a link to the Washington University news release about the U.S. News & World Report undergraduate rankings for 2004-05: http://news-info.wustl.edu/news/page/normal/3627.html To view a full listing of U.S. News magazine, book and Web-only rankings for 2004-05, please visit the U.S. News & World Report site: http://www.usnews.com/usnews/edu/college/rankings/rankindex_brief.php

Breast cancer patients taking the drug Arimidex to prevent recurrence of their disease sometimes suffer from bone, muscle or joint pains. Giving these patients vitamin D supplements can make the pain go away in some cases, according to Washington University physicians who treat cancer patients at the Siteman Cancer Center and Barnes-Jewish Hospital.

Cervical cancers that take up a lot of blood sugar, or glucose, are more resistant to treatment than those that are less glucose-hungry, according to research at the School of Medicine. The researchers also found that the high glucose-uptake tumors can be identified with PET scans, which are already routinely used to determine tumor size and lymph node involvement in cervical cancer patients.

Reporting in the journal Science, Washington University researchers have reaffirmed a method for curing Type 1 diabetes in mice. They try to stop the immune system before it kills off all of the insulin-secreting cells in the pancreas. Read more of this article from the St. Louis Post-Dispatch.