Medicine & Health

WenLeana S. Wen, 23, a current student at Washington University School of Medicine, and Aaron F. Mertz, 22, a recent alumnus from Washington University, have been named Rhodes Scholars, according to an announcement Nov. 18 by The Rhodes Trust. They are among 32 U.S. students chosen from 896 nominees for graduate study at the University of Oxford in England.

Listed below are this month’s featured news stories. • Breaking down Alzheimer’s (week of Nov. 1) • Preventing transplant rejection (week of Nov. 8) • Predicting glaucoma (week of Nov. 15) • No-incision stomach stapling (week of Nov. 22) • Organ donor health (week of Nov. 29)

Investigators at the School of Medicine have developed a model to identify patients at high risk of developing glaucoma. Their research was presented at the annual meeting of the American Academy of Ophthalmology in Las Vegas.

Three Alzheimer’s disease researchers at the School of Medicine in have been named to the 2006 Scientific American 50, an honorary list of the year’s “prime movers” in a variety of scientific disciplines.

ColeF. Sessions Cole, M.D., has been appointed assistant vice chancellor for children’s health at the School of Medicine and chief medical officer at St. Louis Children’s Hospital.

The fact that corporate leaders recognize their industries’ role in social responsibility is not new, but there are relatively few examples that clearly connect this failure to respond with negative changes. One of the best examples is the pharmaceutical giant Merck, which was led by P. Roy Vagelos during a pivotal era in the industry’s history. Vagelos will explore these examples in detail for his talk on “The Social Responsibility of Business” to be held at 4 p.m. Nov. 13 in Graham Chapel.

The large globules in the liver cells on the left are characteristic of alpha-1-antitrypsin deficiency. The image on the right shows normal liver cells.Research performed at Washington University School of Medicine in St. Louis sheds light on the mechanisms that contribute to liver disease in alpha-1-AT deficiency patients. People with alpha-1-deficiency have a genetic mutation that can lead to emphysema at an early age and to liver damage. Using an experimental mouse model of the disorder, the researchers investigated the effects of a non-steroidal anti-inflammatory drug (NSAID) on liver injury.

A simple points system may soon help guide treatment of elderly heart failure patients. Researchers at Washington University School of Medicine in St. Louis found that by counting how many of seven easy-to-obtain health factors a patient has, physicians can estimate the patient’s risk of dying.

On a mammogram, LCIS and ALH typically look like small deposits of calcium.In women whose initial breast biopsies revealed certain rare, yet benign breast conditions, more extensive follow-up surgical biopsies found that up to 25% of them actually had cancer in addition to these benign lesions. Most of the cancers were invasive, meaning the tumors had penetrated normal breast tissue and would require treatment. In the study, conducted at Washington University School of Medicine in St. Louis, the women’s initial biopsies had revealed atypical lobular hyperplasia (ALH) or lobular carcinoma-in-situ (LCIS), conditions that increase the risk of breast cancer, but which are themselves considered benign.

More than 80,000 people in the United States are on waiting lists for organ transplants. Some will have to wait for the death of a matching donor, but more and more people are receiving organs from living donors. In an effort to close the gap between organ supply and demand, researchers at Washington University School of Medicine, the University of Michigan and the American Society of Transplant Surgeons are studying ways to reimburse living donors for some of their out-of-pocket expenses when they choose to donate an organ.