Medicine & Health

A team of researchers from Washington University and the Israeli Institute of Technology (Technion) in Haifa, Israel, has developed a technique to detect the ancestry of disease genes in hybrid, or mixed, human populations.

The ability of brain cells to take in substances from their surface is essential to the production of a key ingredient in Alzheimer’s brain plaques, neuroscientists at the School of Medicine have learned. The researchers used a drug to shut down the intake process, known as endocytosis, in a mouse model of Alzheimer’s disease. The change led to a 70 percent drop in levels of amyloid beta, the protein fragment that clumps together to form Alzheimer’s plaques.

BarchThe Silvio Conte Center for Neuroscience Research at Washington University has a new director. Deanna Barch, associate professor of psychology in Arts & Sciences, of psychiatry and of radiology, takes over leadership of the center from John Csernansky, the former Gregory B. Couch Professor of Psychiatry, who has become the chairman of psychiatry at Northwestern University.

A team of researchers from Washington University in St. Louis that includes Alan R. Templeton and the Israeli Institute of Technology (Technion) in Haifa has developed a technique to detect the ancestry of disease genes in hybrid, or mixed, human populations. The technique, called expected mutual information (EMI), determines how a set of DNA markers is likely to show the ancestral origin of locations on each chromosome.

Heart surgeons at the School of Medicine report that by adding a simple 10-20 second step to an operative procedure they achieved a significant improvement in the outcome for the surgical treatment of atrial fibrillation (AF). The surgeons redirected wayward electrical impulses that cause AF by creating precisely placed scars, or ablations, in the heart muscle.

In the first comprehensive study of the genetic basis of psoriasis, researchers at the School of Medicine have discovered seven new sites of common DNA variation that increase the risk of the troublesome skin condition.

ReissCraig Reiss has been named the Sam and Marilyn Fox Distinguished Professor in Medicine at the School of Medicine. Reiss, a cardiologist, directs the Washington University Cardiology Consultants and the Heart Care Institute at Barnes-Jewish West County Hospital.

Current medications for seizures are comparable to over-the-counter cold and flu remedies: They block symptoms, but don’t significantly affect the underlying illnesses that cause them. Now scientists at the School of Medicine have taken the first step toward developing another option. They’ve used a drug to prevent the brain abnormalities that lead to seizures in mice with an inherited form of epilepsy.

Nanoparticles (yellow) show that a treated tumor (left) has less blood vessel growth than an untreated tumor.Anyone facing chemotherapy would welcome an advance promising to dramatically reduce their dose of these often harsh drugs. Using nanotechnology, researchers at the School of Medicine have taken a step closer to that goal. The researchers focused a powerful drug directly on tumors in rabbits using drug-coated nanoparticles.

Below is a link to the Washington University news release about the U.S. News & World Report undergraduate rankings for 2004-05: http://news-info.wustl.edu/news/page/normal/3627.html To view a full listing of U.S. News magazine, book and Web-only rankings for 2004-05, please visit the U.S. News & World Report site: http://www.usnews.com/usnews/edu/college/rankings/rankindex_brief.php