Medicine & Health

Two international teams of researchers have made significant gains in understanding the genetic basis of psoriasis, a chronic skin condition that can be debilitating in some patients. Their research, involving thousands of patients, is reported in two studies published this week in the advance online Nature Genetics.

A new brain-imaging study is shedding light on what it means to “get lost” in a good book — suggesting that readers create vivid mental simulations of the sounds, sights, tastes and movements described in a textual narrative while simultaneously activating brain regions used to process similar experiences in real life.

Washington University graduate student Kim Lorenz collects yeast samples from Pennsylvania oak trees as part of a project to analyze how genes interact to produce complex traits.In recent years, genetic studies have uncovered hundreds of DNA variations linked to common diseases, such as cancer or diabetes, raising the prospect that scientists can gauge disease risk based on information in an individual’s genome. But the variations identified to date only account for a small percentage – typically one to three percent – of the overall genetic risk of any common disease.

The Master of Public Health Program at the George Warren Brown School of Social Work is accepting applications for its first class.

Lodge Jennifer Lodge has been named associate dean for research at the School of Medicine. The appointment is effective Feb. 1, 2009. In the newly created position, Lodge will coordinate efforts to advance research at the school, focusing particularly on projects that involve multiple departments, multiple disciplines and core facilities that can serve a wide variety of researchers.

Gross (left) and Xianlin Han analyze samplesResearchers at the School of Medicine, led by heart specialist Richard Gross, are studying how altered fat metabolism causes heart failure in diabetic patients. They have received a five-year, $11 million grant from the National Institutes of Health to continue their investigations.

Many older adults worry — a lot. Almost one in 10 Americans over age 60 suffer from an anxiety disorder that causes them to worry excessively about normal things — like health, finances, disability and family. Although antidepressant drugs known as selective serotonin reuptake inhibitors (SSRIs) can improve anxiety symptoms in younger adults, little has been known about their effects in older people. In the largest study of SSRIs in older people with anxiety disorders, a team of psychiatric researchers found the drug escitalopram (Lexapro®) improved anxiety symptoms and quality of life.

McBrideLosing a job usually comes with the double whammy of losing any employer-sponsored health insurance. Timothy McBride, Ph.D., leading health economist and associate dean for public health at WUSTL’s George Warren Brown School of Social Work, is available to discuss current coverage options and the future of health insurance for low-income people. “Health reform, if it is considered in Congress, may provide relief for low-income persons,” he says. “In the short run, there are unfortunately few options for the unemployed unless they are relatively healthy and can buy cheap policies, or have significant savings. It is one of the sad aspects of our broken health-care system.”

David Kilper/WUSTL PhotoWUSTL biomedical engineers Younan Xia (left) and Lihong Wang examine the photoacoustic tomography machine (PAT) in Wang’s Whitaker Building laboratory.Information obtained from a new application of photoacoustic tomography (PAT) is worth its weight in gold to breast cancer patients. For the first time, Lihong Wang, Ph.D., Gene K. Beare Distinguished Professor in the Department of Biomedical Engineering, with a joint appointment in Radiology, and Younan Xia, Ph.D., James M. McKelvey Professor in Biomedical Engineering, with a joint appointment in chemistry in Arts & Sciences, both at Washington University in St. Louis, have used gold nanocages to map sentinel lymph nodes (SLN) in a rat noninvasively using PAT.

Marcia Munk, Universidade Federal de São PauloWhat if free exercise classes were offered in public spaces such as parks, beaches and recreation centers? When a city government in Brazil tried such a program, it greatly increased physical activity among community members. A group of health researchers who studied the program believes it could also work in U.S. cities with warm climates.