Medicine & Health

The first head-to-head comparison of therapeutic monoclonal antibodies produced from plants versus the same antibodies produced from mammalian cells has shown that plant-produced antibodies can fight infection equally well. Scientists conducted the comparison as a test of the potential for treating disease in developing nations with the significantly less expensive plant-based production technique.

Scientists at Washington University School of Medicine in St. Louis have identified a protein made by the malaria parasite that is essential to its ability to take over human red blood cells. “Without this protein … the infectious process stops,” says Dan Goldberg, M.D.

Making flu shots mandatory in 2008 dramatically increased the vaccination rate among St. Louis-based BJC HealthCare’s nearly 26,000 employees to more than 98 percent, according to a study led by the School of Medicine and now online in the journal Clinical Infectious Diseases.

Exposure to severe stress early in life increases the risk of alcohol and drug addiction. Yet surprisingly, some adults sexually abused as children — and therefore at high risk for alcohol problems — carry gene variants that protect them from heavy drinking and its effects, according to researchers at Washington University School of Medicine in St. Louis.

Cleft palate has been linked to dozens of genes. During their investigation of one of these genes, researchers at Washington University School of Medicine in St. Louis were surprised to find that cleft palate occurs both when the gene is more active and when it is less active than normal. 

Washington University School of Medicine in St. Louis has received a five-year, $13 million grant from the Bill & Melinda Gates Foundation to improve efforts to eliminate two parasitic diseases, elephantiasis and river blindness. The award is believed to be the largest global health grant so far to the University.

A type of antibiotic that can cause hearing loss in people has been found to paradoxically protect the ears when given in extended low doses in very young mice. The surprise finding came from researchers at Washington University School of Medicine in St. Louis who looked to see if loud noise and the antibiotic kanamycin together would produce a bigger hearing loss than either factor by itself.

The largest U.S. epidemiological study of Parkinson’s disease has found that the disease is more prevalent in the Midwest and the Northeast and is twice as likely to strike whites and Hispanics as blacks and Asians. Researchers analyzed data on more than 36 million Medicare recipients.

Washington University School of Medicine and St. Jude Children’s Research Hospital announced in a Jan. 25 news conference in Washington, D.C., an unprecedented effort to identify the genetic changes that give rise to some of the world’s deadliest childhood cancers.

HIV infection or the treatments used to control it are prematurely aging the brain, researchers at Washington University School of Medicine in St. Louis and the University of California-San Diego have found. Blood flow in the brains of HIV patients is reduced to levels normally seen in uninfected patients 15 to 20 years older.