Unlikely gene variants work together to raise Alzheimer’s risk

Studying spinal fluid from people at risk for Alzheimer’s disease, School of Medicine researchers have found that a gene variation that had not been considered risky actually can increase the chances of developing Alzheimer’s disease when it occurs in tandem with another gene variant known to elevate risk. Shown is an image of a brain with a buildup of amyloid deposits (highest amounts in yellow and red) that collect to form senile plaques in patients with Alzheimer’s.

Study suggests private NICU rooms may influence preemies’ development

Premature babies often spend their first months of life in neonatal intensive care units (NICUs) — environments that, in recent years, have seen transformations, with hospitals adding private rooms to NICUs in place of open wards. But research at the School of Medicine adds new information to the discussion over what is the optimal setting for infants in the NICU. Shown is the study’s first author, Bobbi Pineda, PhD, in the NICU at St. Louis Children’s Hospital.

Genetic errors identified in 12 major cancer types

By analyzing the DNA in more than 3,000 tumors, scientists led by Li Ding, PhD, at The Genome Institute have identified 127 repeatedly mutated genes that likely drive the growth of a range of cancers in the body. The discovery sets the stage for devising new diagnostic tools and more personalized cancer treatments.
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