Medicine & Health

A new study at the School of Medicine is focused on understanding how the pathways identified by the Human Connectome Project differ in people with psychiatric illnesses. Principal investigator Daniel Mamah, MD, said the group’s goal is to look at diagnosing psychiatric illness in a different way.

Using antibodies from camels and alpacas, scientists led by David T. Curiel, MD, PhD, at Washington University School of Medicine in St. Louis have found a way to deliver anticancer viruses directly to tumor cells, leaving other types of cells uninfected. The discovery may solve a longstanding problem in the field of gene therapy.

The genome is the instruction book for life. But reading that instruction book and carrying out its directives are controlled by the epigenome, which attaches chemical markers to DNA to activate or silence genes. For the first time, researchers at the School of Medicine and elsewhere have assembled a comprehensive map of the human epigenome. 

The DNA of bacteria that live in the body can pass a trait to offspring in a way similar to the parents’ own DNA, a new mouse study suggests. According to the authors, the discovery means scientists need to consider a significant new factor – microbial DNA– in their efforts to understand how genes influence illness and health.

More rural Americans are signing up for Medicare Advantage despite reductions in payments, according to new research from the Brown School at Washington University in St. Louis. Extra benefits may be among the likely reasons, says study co-author Timothy McBride, PhD, professor at the Brown School.

Beavers don’t brush their teeth, and they don’t drink fluoridated water, but a new study reports beavers do have protection against tooth decay built into the chemical structure of their teeth: iron. The research team, which was led by scientists from Northwestern University, included Jill D. Pasteris, PhD, professor of earth and planetary sciences in Arts & Sciences.

Sarah K. England, PhD, a professor of obstetrics and gynecology, has been named the inaugural Alan A. and Edith L. Wolff Professor of Medicine at the School of Medicine.

Children treated for moderate acute malnutrition experience a high rate of relapse and even death in the year following treatment and recovery. A new study led by School of Medicine researchers has found that target weights and measures of arm circumference used in assessing the health of malnourished children are insufficient and that raising these thresholds could significantly lower the rate of relapse.

​Restoring function after spinal cord injury, which damages the connections that carry messages from the brain to the body and back, depends on forming new connections between the surviving nerve cells. With a five-year, nearly $1.7-million grant from the National Institutes of Health, Shelly Sakiyama-Elbert, PhD, professor of biomedical engineering in the School of Engineering & Applied Science, is using novel methods to study how these nerve cells grow and make new connections to reroute signals that could restore function and movement in people with these debilitating injuries.

Factors associated with the prevalence of diabetes vary by geographic region in the United States, according to new research from the Brown School at Washington University in St. Louis led by J. Aaron Hipp, PhD. The findings suggest that approaches to combating the disease should be localized.