Medicine & Health

A diabetes drug may have benefits beyond lower blood sugar in patients with HIV. New research from the laboratory of Kevin E. Yarasheski, PhD, suggests the drug may prevent cardiovascular problems because it works to reduce inflammation that is linked to heart disease and stroke in these patients. The drug both improved metabolism and reduced inflammation in HIV-positive adults on antiretroviral therapy.

​To the nearly 2 million people in the United States living with the loss of a limb, prosthetic devices provide restored mobility, yet lack sensory feedback. A team of engineers and researchers at Washington University is working to change that so those with upper limb prosthetics can feel hot and cold and the sense of touch through their prosthetic hands.

A newly discovered link between bacteria and immune cells sheds light on inflammatory bowel disease, an autoimmune condition that affects 1.6 million people in the United States, according to researchers at Washington University School of Medicine in St. Louis.

Researchers led by John F. DiPersio, MD, PhD, at the School of Medicine have designed a way to mitigate graft-versus-host disease, a common and often life-threatening complication of bone marrow transplants that are used to treat leukemia and other blood cancers. The method also employs a molecular imaging tool to help doctors identify patients most likely to develop this dangerous condition.

The Washington University AIDS Clinical Trials Unit is the first in the nation to open a clinical trial evaluating whether statins reduce heart attacks and strokes in patients with human immunodeficiency virus (HIV).

Researchers have uncovered a unique connection between diabetes and Alzheimer’s disease, providing further evidence that a disease that robs people of their memories may be affected by elevated blood sugar, according to scientists at Washington University School of Medicine in St. Louis.

Philip Needleman, PhD, former chair of the Department of Pharmacology at Washington University School of Medicine in St. Louis, has been elected a fellow of the American Academy of Arts and Sciences.

Washington University School of Medicine and the Brown School have received a $4 million grant to study whether a new model of providing family planning services can reduce unintended pregnancies and births. As part of the study, they are recruiting 10,000 women of child-bearing age in the St. Louis area to participate.

Washington University School of Medicine neuroscientists, led by Michael R. Bruchas, PhD, assistant professor of anesthesiology and of neurobiology, have attached the light-sensing protein rhodopsin to opioid receptor parts to activate the receptor pathways using light from a laser fiber-optic device. They also influenced the behavior of mice using light, rather than drugs, to activate the reward response.

Fragile X syndrome, an inherited cause of autism and intellectual disability, can have consequences even for carriers of the disorder who don’t have full-blown symptoms. Researchers at Washington University School of Medicine in St. Louis have identified a potential target for treatment for fragile X carriers.