Medicine & Health

​While the federal health-care law has reduced the number of uninsured people by about 10 million, challenges remain, including how to educate new enrollees about their coverage options. New research at Washington University shows that communicating information about the Affordable Care Act can be made simple.

Personalized melanoma vaccines can be used to marshal a powerful immune response against unique mutations in patients’ tumors, according to early data in a first-in-people clinical trial at Washington University School of Medicine in St. Louis. The research is a boost to cancer immunotherapy, a treatment strategy that unleashes the immune system to seek out and destroy cancer.

Older mice genetically prone to bear offspring with heart defects can reduce this risk to that of younger mouse mothers with the same genetic defect through exercise alone, according to new research at the School of Medicine. The study, led by Patrick Y. Jay, MD, PhD, also suggests that the increased risk of congenital heart defects is tied to the age of the mother and not the age of her eggs.

​Using a new high-speed, high-resolution imaging method, Lihong Wang, PhD, and his team at Washington University in St. Louis were able to see blood flow, blood oxygenation, oxygen metabolism and other functions inside a living mouse brain at faster rates than ever before.​

Many kidney disorders are difficult to diagnose. To address this problem, scientists and clinicians have developed a diagnostic test that identifies genetic changes linked to inherited kidney disorders. This testing is now available nationwide through Genomic Pathology Services (GPS) at the School of Medicine.

Antibiotic resistance is poised to spread rapidly around the globe among bacteria frequently implicated in respiratory and urinary infections in hospital settings, according to new research at the School of Medicine.

​William Gillanders, MD, a physician-scientist and avid cyclist, keeps the wheels turning in the race against breast cancer. His career goal is to change treatment paradigms by making breast cancer vaccines a reality for those being treated for the disease.

Finding kidney cancer early has been among the disease’s greatest challenges. Now, researchers at Washington University School of Medicine in St. Louis have developed a noninvasive method to screen for kidney cancer that involves measuring the presence of proteins in the urine.

A deficiency of vitamin D has been linked to Type 2 diabetes and heart disease, two illnesses that commonly occur together and are the most common cause of illness and death in Western countries. Now, new research in mice led by the School of Medicine’s Carlos Bernal-Mizrachi suggests vitamin D plays a major role in preventing the inflammation that leads to Type 2 diabetes and atherosclerosis.

In cells lining the airway, high levels of certain proteins have long been linked with the overproduction of mucus characteristic of diseases like asthma and COPD. New research from the School of Medicine provides clues to potentially counteract inappropriate mucus production.