New strategy to lower blood sugar may help in diabetes treatment
Working in mice, researchers at Washington University School of Medicine in St. Louis led by Brian N. Finck, PhD (left), and Kyle S. McCommis, PhD, showed they could reduce glucose production in the liver and lower blood sugar levels. Their approach — shutting down a liver protein involved in making glucose — may help treat type 2 diabetes.
Plax named Ferring chair in pediatrics
Katie Plax, MD, who is recognized widely for an innovative youth outreach center she started and for her work advocating for children and teens, has been named the Ferring Family Chair in Pediatrics at St. Louis Children’s Hospital and Washington University School of Medicine in St. Louis.
Reward, aversion behaviors activated through same brain pathways
New research may help explain why drug treatments for addiction and depression don’t work for some patients. The conditions are linked to reward and aversion responses in the brain. And the research suggests that some treatments simultaneously stimulate reward and aversion responses, resulting in a net zero effect.
Drastically cutting calories lowers some risk factors for age-related diseases
The largest study to date of sustained calorie reduction in adults shows that it does not produce all of the metabolic effects associated with longevity that have been found in animal studies. Severely cutting calorie intake, however, did appear to lower the risk of cardiovascular disease and make people more sensitive to insulin, according to John O. Holloszy, MD, principal investigator at the study’s Washington University clinical site.
In very ill, probiotics don’t prevent ‘superbugs’ from settling in intestinal tract
Compared with routine medical care, probiotics administered to critically ill patients in intensive care units showed no benefit in preventing the colonization of drug-resistant microbes in the intestinal tract, according to new research at Washington University School of Medicine in St. Louis.
Relapse, poor survival in acute leukemia linked to genetic mutations that persist in remission
For patients with an often-deadly form of leukemia, new research by Timothy J. Ley, MD, and colleagues suggests that lingering cancer-related mutations – detected after initial treatment with chemotherapy – are associated with an increased risk of relapse and poor survival.
Quitting smoking after heart attack gives quick boost to mental health, quality of life
A new study shows that quitting smoking after a heart attack has immediate benefits, including less chest pain, better quality of daily life and improved mental health. Many of these improvements became apparent as little as one month after quitting and are more pronounced after one year, according to the research led by Sharon Cresci, MD, at the School of Medicine.
Many parents unaware of e-cigarette dangers to children
As the use of e-cigarettes has risen dramatically in the United States in recent years, so have calls to poison centers about them. Yet many parents who use e-cigarettes – or “vape” – aren’t aware of the dangers to children, according to a study at the School of Medicine.
$7 million grant aids efforts to eliminate neglected tropical diseases
Researchers at Washington University School of Medicine in St. Louis have received a $7 million grant from the Bill & Melinda Gates Foundation aimed at eliminating river blindness and elephantiasis, two neglected tropical diseases that annually sicken millions.
New clues found to vision loss in macular degeneration
Scientists have identified a pathway that leads to the formation of atypical blood vessels that can cause blindness in people with age-related macular degeneration. The research, at Washington University School of Medicine in St. Louis, sheds light on one of the leading causes of blindness in industrialized countries and offers potential targets for treating the disease.
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