Medicine & Health

The School of Medicine has received a $4.3 million award from the Alzheimer’s Association to expand a major international clinical trial evaluating whether drugs can prevent Alzheimer’s disease in patients genetically predisposed to develop the devastating disease at a young age.

Researchers at the School of Medicine have found that a program aimed at helping abused and neglected children and their families is improving outcomes for kids and providing children with stable home environments as their cases move through the courts.

A team at Washington University School of Medicine in St. Louis has identified a single gene pathway that is vital for Zika and other flaviviruses to spread infection between cells.

New research from the School of Medicine suggests that mothers who eat high-fat, high-sugar diets can predispose multiple generations to metabolic problems, even if their offspring consume healthy diets.

As young people reach adulthood, preferences for sweet foods typically decline. But for people with obesity, research from the School of Medicine suggests that the drop-off may not be as steep and that the brain’s reward system operates differently in obese people than in thinner people. The findings are published in the journal Diabetes.

New Alzheimer’s disease research details a technique that speedily measures levels in the brain of a damaging protein fragment, and insight into why mutations in a specific gene increase the risk of developing the disease. Both studies, from researchers at Washington University School of Medicine in St. Louis, are available online in The Journal of Experimental Medicine.

Examining databases of proteins’ 3-D shapes, scientists at School of Medicine have identified more than 850 DNA mutations that appear to be linked to cancer. The information may expand the number of cancer patients who can benefit from existing drugs. The study, published June 13 in Nature Genetics, detailed a list of the mutations and associated drugs that may work against them.

With research that points to potential therapeutic targets for autoimmune diseases, researchers at Washington University School of Medicine in St. Louis have identified genetic master switches that turn up – or down – the activity of specific types of immune cells.

New research at Washington University School of Medicine in St. Louis indicates stem cells located in “pockets” in the intestine avoid contact with a prominent metabolite produced by beneficial microbes living in the gut. That metabolite – butyrate – restricts the proliferation of stem cells, potentially hampering the intestine from repairing itself after an injury or damage.

Studying twins from birth through age 2, scientists at Washington University School of Medicine in St. Louis have shown that the gut’s immune system develops in sync with the gut’s tens of trillions of microbes. The findings have implications for understanding healthy growth and, potentially, the origins of various immune disorders.