Medicine & Health

School of Medicine researchers have identified a compound that targets the APOE protein in the brains of mice and protects against damage induced by the Alzheimer’s protein amyloid beta.

About half of people with blood clots in the deep veins of their legs develop a complication that involves chronic limb pain and swelling, making it difficult for some to walk and perform daily activities. A large-scale clinical trial has shown that a risky, costly procedure to remove such clots fails to reduce the likelihood that patients will develop the debilitating complication.

A new study hints that even large physician practices may have trouble moving to a payment system that rewards quality of health care over quantity of services delivered. And the new system may disproportionately burden small practices, researchers found.

Researchers at Washington University School of Medicine in St. Louis have identified a way to prevent fat cells from growing larger, a process that leads to weight gain and obesity. By activating a pathway in fat cells in mice, the researchers found they could feed the animals a high-fat diet without making them obese.

Why move from current standards of patient care to a more personalized approach to treatment? Experts at the School of Medicine describe today’s medical landscape as they plan for the care — and cures — of the future.

The School of Medicine is building the necessary infrastructure through centers and institutes to allow research that is more efficient and cost-effective, and that encourages high risks leading possibly to key breakthroughs.

Timothy Ley, MD, has been investigating leukemia, particularly acute myeloid leukemia (AML), for decades. His research team now knows the mutations they need to go after ­aggressively, the nature of the ­mutations that need to be targeted and why patients relapse.

At Washington University, training the next generation of leaders in translational medicine is a key focus. Here, Cheryl Leyns and Phat Huynh share stories of working in the lab of David Holtzman, MD, researching pathologies of Alzheimer’s disease.

Faculty at the Envolve Center for Health Behavior Change, a collaboration among Washington University, Duke University and Centene Corp., share what it takes to make bad habits into good ones.

As a survivor of sex trafficking, Katie Rhoades, MSW ’11, is passionate about helping women in the commercial sex industry. After graduating from the Brown School, she founded Healing Action, a nonprofit that helps women move on from their trauma.