Medicine & Health

Investigators at Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine in St. Louis have been awarded a $15 million grant to better understand the genetic changes that drive acute myeloid leukemia (AML), a deadly blood cancer, and predict patients’ responses to therapy. The findings also may enable investigators to develop more effective therapies tailored to patients, based on the genetic characteristics of their cancer cells.

Researchers at the School of Medicine have discovered that an initial urinary tract infection (UTI) triggers changes to immune and other cells in the bladder that can prime the bladder to overreact to bacteria, worsening subsequent UTIs.

A new study from the School of Medicine finds that African American children with mild asthma can take their steroid inhalers as needed, based on symptoms, rather than at set times daily regardless of symptoms.

A team led by researchers at the School of Medicine in St. Louis has identified a pair of genes that influence risk for Alzheimer’s disease. The genes — known as MS4A4A and TREM2 — affect the brain’s immune cells. They influence Alzheimer’s risk by altering levels of TREM2, a protein that is believed to help microglia cells clear excessive amounts of the Alzheimer’s proteins amyloid and tau from the brain.

Researchers at the School of Medicine have found the molecular signature of a healthy gut microbial community – the kind that can keep the intestinal bacteria Clostridium difficile (C. difficile) from overgrowing and causing diarrhea.

Research from Washington University in St. Louis finds that mutations of a gene implicated in long QT syndrome in humans may trigger seizures because of their direct effects on certain classes of neurons in the brain — independent from what the genetic mutations do to heart function. The new work from Arts & Sciences was conducted with fruit flies and is published August 8 in PLOS Genetics.

In a new study involving a researcher from Washington University in St. Louis’ Olin Business School, the co-authors discovered something they say surprised them: Medicare Part D’s setup actually inhibits insurers from seeking higher subsidies from the government. It keeps subsidies in check by virtue of the way it’s designed.

A blood test to detect the brain changes of early Alzheimer’s disease has moved one step closer to reality. Researchers from the School of Medicine report that they can measure levels of the Alzheimer’s protein amyloid beta in the blood and use such levels to predict whether the protein has accumulated in the brain.

Physicians at Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine in St. Louis have been awarded a six-year, $7.8 million grant from the National Cancer Institute (NCI) to play a leading role in designing, conducting and enrolling patients in clinical trials through the NCI’s National Clinical Trials Network.

A study of the genetics of the people of Finland, conducted in part by researchers at the School of Medicine, has revealed new clues to common diseases.