Medicine & Health

Itching is one of the most prevalent side effects of powerful, pain-killing drugs like morphine, oxycodone and other opioids. For many years, scientists have scratched their own heads about why the drugs so often induce itch while they are suppressing pain. Now researchers at Washington University School of Medicine in St. Louis have shown they can control the opioid-induced itching without interfering with a drug’s ability to relieve pain.  

Sports medicine specialists at Washington University School of Medicine in St. Louis, including Rick Wright, MD, and Corey Gill, MD, are leading a national study analyzing why a second surgery to reconstruct a tear in the knee’s anterior cruciate ligament (ACL) carries a high risk of bad outcomes. Between 1 percent to 8 percent of ACL repairs fail. Most patients then opt to have a second operation, but the failure rate for those subsequent surgeries is almost 14 percent.

Although clubfoot is one of the most common congenital birth defects, few genetic causes have been found. Now, researchers at Washington University School of Medicine in St. Louis have found what they believe to be the most common cause of inherited clubfoot yet discovered.  

Researchers at Washington University School of Medicine in St. Louis have identified a parasite protein that has all the makings of a microbial glass jaw: it’s essential, it’s vulnerable and humans have nothing like it, meaning scientists can take pharmacological swings at it with minimal fear of collateral damage.

Most people at risk for developing glaucoma due to high eye pressure do not need treatment, according to a large, multi-center study.

Pig heart valves used to replace defective aortic valves in human patients failed much earlier and more often than expected, says a report from cardiac surgeons at the School of Medicine. This is the first report to demonstrate this potential problem, the researchers say.

Top: normal lungs. Bottom: asthmatic lungs.Many young children who get a severe skin rash develop asthma months or years later. Doctors call the progression from eczema, or atopic dermatitis, to breathing problems the atopic march. Now scientists at the School of Medicine have uncovered what might be the key to atopic march. They’ve shown that a substance secreted by damaged skin circulates through the body and triggers asthmatic symptoms in allergen-exposed laboratory mice.

Bacteria that cause urinary tract infections make more tools for stealing from their host than friendly versions of the same bacteria found in the gut.

People have long prized silver as a precious metal. Now, silver-coated endotracheal tubes are giving critically ill patients another reason to value the lustrous metal. In a study published in the Aug. 20, 2008 issue of the Journal of the American Medical Association, researchers at the School of Medicine and the NASCENT Investigation Group, report that the silver-coated tubes led to a 36 percent reduction of ventilator-associated pneumonia.

Scanning electron microscopy image of a filamentous bacterium from a patient with a UTIScientists at the School of Medicine have found definitive proof that some of the bacteria that plague women with urinary tract infections (UTIs) are entrenched inside human bladder cells. The finding confirms a controversial revision of scientists’ model of how bacteria cause UTIs. Previously, most researchers assumed that the bacteria responsible for infections get into the bladder but do not invade the individual cells that line the interior of the bladder.