Medicine & Health

A policy change regarding the rules of lung distributions for transplants has had several unintended consequences, according to a new study from the School of Medicine.

Removing one gene caused normal muscle muscle fibers to grow to three times their normal size. Researchers at the School of Medicine have found that targeting a protein related to that gene with lithium can reduce muscle wasting in a rare form of muscular dystrophy.

Pregnancy tests can sometimes give a false negative result to women several weeks into their pregnancies, according to research by Ann Gronowski, professor of pathology and immunology at the School of Medicine. Her findings led the FDA to change its standards for evaluating new pregnancy tests, but old tests with the false-negative problem are still on the market.

Robert W. Gereau, the Dr. Seymour and Rose T. Brown Professor of Anesthesiology at Washington University School of Medicine, is working to discover the genetic and molecular roots of pain, with a goal of reversing the processes that cause pain and make it so disabling.

Probiotics – living bacteria taken to promote digestive health – evolve once inside the body and have the potential to become less effective and sometimes even harmful, according to a new study from the School of Medicine. The findings suggest that developers of probiotic-based therapeutics must consider how the probiotics might change after administration.

Pain researchers at the School of Medicine have shown in rodents that they can block receptors on brain cells that are responsible for the negative emotions associated with pain, such as sadness, depression and lethargy. The findings could lead to new, less addictive approaches to pain treatment.

Researchers at the School of Medicine have found a compound that may treat inflammatory bowel disease without directly targeting inflammation. The compound tamps down the activity of a gene linked to blood clotting.

With the aid of a grant from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health, School of Medicine researchers are studying why immunity elicited by the flu vaccine wanes so rapidly. The goal is a better, longer-lasting flu vaccine.

Over-testing for urinary tract infections (UTIs) leads to unnecessary antibiotic use, which spreads antibiotic resistance. Infectious disease specialists at the School of Medicine made changes to hospital procedures that cut urine tests by nearly half without compromising doctors’ abilities to detect UTIs.

A School of Medicine study of adults with lumbar scoliosis and found that the most important factor in determining whether to do surgery is the extent of a patient’s disability due to his or her spinal deformity, as well as how much that disability interferes with day-to-day life.