Medicine & Health

A new study at the School of Medicine finds disparities between African-Americans and Caucasians in a key biomarker for Alzheimer’s disease — suggesting that tools to diagnose the disease in Caucasian populations may not work as well in African-Americans.

A long-term study of adult children of Alzheimer’s patients — led by the School of Medicine — aims to define who is likely to develop the disease and when, and to establish a timeline for how quickly the disease will progress.

Chronic poor sleep has been linked to cognitive decline. A new study from the School of Medicine shows that a sleepless night causes levels of the Alzheimer’s protein amyloid beta to rise faster than the brain’s waste-disposal system can remove it. Persistently high levels of the protein can set off a cascade of brain changes leading to dementia.

Using a new imaging agent that binds to tau protein and makes it visible in positron emission tomography (PET) scans, scientists at Washington University School of Medicine in St. Louis have shown that measures of tau are better markers of the cognitive decline characteristic of Alzheimer’s than measures of amyloid beta seen in PET scans.

An international consortium of researchers, including scientists at the Genome Sequencing Center, has decoded the genome of the rhesus macaque monkey and compared it with the genomes of humans and their closest living relatives – the chimps – revealing that the three primate species share about 93 percent of the same DNA. Washington University scientists also recently completed the raw sequences for the orangutan and marmoset genomes.