Researchers close in on origins of main ingredient of Alzheimer’s plaques

The ability of brain cells to take in substances from their surface is essential to the production of a key ingredient in Alzheimer’s brain plaques, neuroscientists at the School of Medicine have learned. The researchers used a drug to shut down the intake process, known as endocytosis, in a mouse model of Alzheimer’s disease. The change led to a 70 percent drop in levels of amyloid beta, the protein fragment that clumps together to form Alzheimer’s plaques.

Technique traces origins of disease genes in mixed races

A team of researchers from Washington University in St. Louis that includes Alan R. Templeton and the Israeli Institute of Technology (Technion) in Haifa has developed a technique to detect the ancestry of disease genes in hybrid, or mixed, human populations. The technique, called expected mutual information (EMI), determines how a set of DNA markers is likely to show the ancestral origin of locations on each chromosome.

Geologist decries floodplain development

Photo courtesy of USGSLevees are not infalliable.Midwesterners have to be wondering: Will April be the cruelest month? Patterns in the Midwest this spring are eerily reminiscent of 1993 and 1994, back-to-back years of serious flooding. Parallels this year include abnormally high levels of precipitation in late winter and early spring, early flooding in various regions, and record amounts of snow in states upstream. One thing Midwesterners have not learned is “geologic reality,” says Robert E. Criss, Ph.D., professor of earth and planetary sciences in Arts & Sciences at Washington University in St. Louis.

Graduate and Professional Rankings of WUSTL by News Media

Below is a link to the Washington University news release about the U.S. News & World Report undergraduate rankings for 2004-05: http://news-info.wustl.edu/news/page/normal/3627.html To view a full listing of U.S. News magazine, book and Web-only rankings for 2004-05, please visit the U.S. News & World Report site: http://www.usnews.com/usnews/edu/college/rankings/rankindex_brief.php

Older women, not men, have a hard time maintaining muscle mass

Women over age 65 have a harder time preserving muscle than men of the same age, which probably affects their ability to stay strong and fit, according to research conducted at the School of Medicine and the University of Nottingham in the United Kingdom. For the first time, scientists have shown it is more difficult for older women to replace muscle that is lost naturally because of key differences in the way their bodies process food.
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