Specialist enzymes make E. coli antibiotic resistant at low pH
New research from Arts & Sciences suggests that many “redundant” enzymes are actually specialists that ensure maximal growth across different environments. They also seem to increase resistance to antibiotics in conditions like those in the GI tract or urinary tract — raising concerns that current antibiotic susceptibility tests are inadequate.
Tidying up: A new way to direct trash to autophagy
Marie Kondo herself couldn’t do it any better. Now researchers at Washington University in St. Louis have uncovered a previously unknown structural feature of living cells that is critical to tidying up.
Rusted root: Weedy rice repeatedly evolves ‘cheater’ root traits
Researchers led by Kenneth M. Olsen in Arts & Sciences used a new imaging technique to reveal a takeover strategy that has worked for weedy rice over and over again: roots that minimize below-ground contact with other plants.
‘Featherweight oxygen’ discovery opens window on nuclear symmetry
Researchers in Arts & Sciences have discovered and characterized a new form of oxygen dubbed “featherweight oxygen” — the lightest-ever version of the familiar chemical element oxygen, with only three neutrons to its eight protons.
How electricity-eating microbes use electrons to fix carbon dioxide
Led by Arpita Bose, assistant professor of biology in Arts & Sciences, a Washington University team showed how an electricity-eating microbe takes up electrons from conductive substances like metal oxides or rust to reduce carbon dioxide. The work is described in the journal Nature Communications.
Washington People: Erik Herzog
Erik Herzog, professor of biology in Arts & Sciences, studies the molecules, cells and circuits of mammalian circadian timing. He also supports and encourages younger neuroscience researchers, from elementary school all the way through doctoral programs.
WashU Expert: The eternal sunshine of perennial ‘wintertime’
The movement to abolish clock-time changes each spring and fall is growing — and so is the scientific evidence. Experts say perennial standard time, or “wintertime,” is the best and safest option for public health.
Engineering proteins to help counter devastating diseases
Meredith Jackrel, assistant professor of chemistry in Arts & Sciences, recently received a five-year grant from the National Institutes of Health (NIH) and another from the Longer Life Foundation to study protein disaggregases — evolved protein forms that mitigate protein misfolding — as a strategy to combat neurodegenerative diseases such as Alzheimer’s, Parkinson’s and ALS.
Blodgett awarded CAREER grant to study biosynthetic silence
Joshua Blodgett, assistant professor of biology in Arts & Sciences, received a five-year $900,500 grant to support his research related to actinomycete bacteria. This type of bacteria produces a majority of current antibiotics and may harbor other useful small molecules that could be revealed by activating silent genes.
Energy, environment focus of 2019 McDonnell lecture
Richard Alley, the Evan Pugh Professor of Geosciences at Pennsylvania State University, will deliver the McDonnell Distinguished Lecture on March 6 at Washington University in St. Louis. Alley’s lecture is titled “Finding the Good News on Energy and Environment.”
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