Author: Julia Evangelou Strait

Studying leukemia in mice, John F. DiPersio, MD, PhD, and his colleagues at Washington University School of Medicine in St. Louis, have reduced a life-threatening complication of stem cell transplants, the only curative treatment when leukemia returns. ​​

Lung cancer patients with a history of smoking have ten times more genetic mutations in their tumors than those with the disease who have never smoked, according to Richard K. Wilson, PhD, and his colleagues at Washington University School of Medicine in St. Louis.

A nationwide consortium of scientists has reported the first comprehensive genetic analysis of squamous cell carcinoma of the lung, a common type of lung cancer responsible for about 400,000 deaths each year. According to Ramaswamy Govindan, MD, of Washington University School of Medicine in St. Louis, about 75 percent of the tumors studied have mutations that can be targeted with existing drugs.

Giving antibiotics before cesarean section surgery rather than just after the newborn’s umbilical cord is clamped cuts the infection rate at the surgical site in half, according to infection disease specialist David K. Warren, MD, and his colleagues at Washington University School of Medicine in St. Louis and Barnes-Jewish Hospital.

Researchers, led by Jean E. Schaffer, MD, at Washington University School of Medicine in St. Louis have received a $4.7 million grant from the National Heart, Lung, and Blood Institute to investigate heart disease in patients with diabetes.

Cardiologists, including Samuel A. Wickline, MD, at Washington University School of Medicine in St. Louis have developed a noninvasive imaging technique that may help determine whether children who have had heart transplants are showing early signs of rejection. The technique could reduce the need for these patients to undergo invasive imaging tests every one to two years.

Researchers led by Michael H. Tomasson, MD, at Washington University School of Medicine in St. Louis have shown how an aggressive form of multiple myeloma resists chemotherapy. Multiple myeloma is a rare cancer of plasma cells in the bone marrow. Though the finding has no immediate benefit for patients, the scientists say it could help guide research into better treatments.

A protein required to regrow injured peripheral nerves has been identified by researchers at Washington University School of Medicine in St. Louis. The finding, in mice, has implications for improving recovery after nerve injury in the extremities. It also opens new avenues of investigation toward triggering nerve regeneration in the central nervous system, notorious for its inability to heal.

Studying mice and humans, researchers at Washington University School of Medicine in St. Louis and their collaborators in Paris have identified two proteins that are required to maintain a supply of stem cells in the developing kidney. The work is a small step toward the future goal of growing kidney stem cells in the lab.

Researchers at Washington University School of Medicine in St. Louis have received a $3 million grant from the National Cancer Institute (NCI) to develop a triple threat in the fight against cancer: a single virus equipped to find, image and kill cancer cells, all at once.