Existing drugs may help more with breast cancer

More patients can benefit from highly effective breast cancer drugs that are already available, according to an analysis of DNA sequencing studies by Ron Bose, MD, PhD, and his colleagues at Washington University School of Medicine in St. Louis and other institutions.

Drugs limiting excess mucus could save lives

Respiratory conditions that restrict breathing such as asthma and chronic obstructive pulmonary disease (COPD) are common killers worldwide. But no effective treatments exist to address the major cause of death in these conditions — excess mucus production. Now, Washington University researchers have described the molecular pathway responsible for excess mucus in airway cells and have used that information to design a series of new drugs that inhibit that pathway.

Washington People: John F. DiPersio

Every year, Siteman Cancer Center hosts a gathering for former bone marrow transplant patients, their families and the staff who helped care for them. It’s a celebration of survival. And every year, John F. DiPersio, MD, PhD, chief of the Division of Oncology, looks out over the audience and marvels. From the lab to the clinic, DiPersio’s work is guided by his commitment to his patients. ​​

$50 million to speed discoveries for patients

The School of Medicine has received a $50 million grant to help speed the translation of scientific discoveries into improvements in human health. The grant supports the School of Medicine’s Institute of Clinical and Translational Sciences, led by Bradley A. Evanoff, MD.

$9 million to investigate blood-clotting disorders

Researchers at Washington University School of Medicine in St. Louis have received a $9 million grant to investigate blood-clotting disorders. From heart attacks and strokes to uncontrolled bleeding, clotting disorders cause more deaths each year in the United States than all types of cancer combined.

Clue to Alzheimer’s cause found in brain samples

Researchers at Washington University School of Medicine in St. Louis have found a key difference in the brains of people with Alzheimer’s disease and those who are cognitively normal but still have the brain plaques that characterize this type of dementia.
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