Author: Julia Evangelou Strait

Doctors at the School of Medicine have shown that testing cervical tumors before treatment for vulnerability to chemotherapy predicts whether patients will do well or poorly with standard treatment. The study supports the future possibility of personalized medicine for cervical cancer, a tumor normally addressed with a one-size-fits-all approach. Pictured is a cervical tumor visible on a PET/CT scan.

Burton E. Sobel, MD, internationally known leader in cardiovascular medicine, prolific scientist and former longtime director of the Cardiovascular Division at Washington University School of Medicine in St. Louis, died Friday, May 3, 2013, at his home in Vermont, after a long illness. He was 75.

Many medical conditions destroy nerve axons, the long wires that transmit signals to other parts of the body. Now, researchers have found a way the body can remove injured axons, identifying a potential target for new drugs that could prevent the inappropriate loss of axons and maintain nerve function.

School of Medicine researchers have discovered why breast cancer patients with dense breasts are more likely than others to develop aggressive tumors that spread. The finding opens the door to drug treatments that prevent metastasis. Shown are collagen fibers at the boundary of a tumor. Fibers that tend to be perpendicular to the tumor’s surface indicate a poor prognosis.

School of Medicine faculty member Elliot L. Elson, PhD, has been elected a fellow of the American Academy of Arts and Sciences. The organization was formed in 1780 to cultivate the arts and sciences and to recognize individuals who have made prominent contributions to their disciplines and to society.

School of Medicine researchers have described a missing link in understanding how damage to the body’s cellular power plants leads to Parkinson’s disease and some forms of heart failure. A mouse heart, in gray, shows signs of heart failure because it is missing a newly discovered key molecule in the process that culls unhealthy mitochondria from cells. Superimposed on the heart is a fruit fly heart tube, shown in color. It shows signs of failure because it is missing another key molecule in mitochondrial quality control.

Washington University School of Medicine in St. Louis is playing a leading role in one of the National Institutes of Health’s first clinical trials to improve treatments for rare and neglected diseases. In this case, the disease is Niemann-Pick Type C, a disorder that causes excess cholesterol to accumulate in the brain, liver and spleen. It affects about 500 children worldwide, leads to neurodegeneration, and usually causes death in the first two decades of life.

Nanoparticles carrying a toxin found in bee venom can destroy human immunodeficiency virus (HIV) while leaving surrounding cells unharmed, researchers at the School of Medicine have shown. The finding is an important step toward developing a vaginal gel that may prevent the spread of HIV.  Shown are nanoparticles (purple) carrying melittin (green) that fuse with HIV (small circles with spiked outer ring), destroying the virus’s protective envelope.

Cancer drugs should kill tumors, not encourage their spread. But new evidence suggests that an otherwise promising class of drugs may actually increase the risk of tumors spreading to bone, according to researchers at Washington University School of Medicine in St. Louis.

Two new studies from the School of Medicine suggest ways to improve surgical treatment for a debilitating condition caused by compressed nerves in the neck and shoulder. The condition, neurogenic thoracic outlet syndrome, causes pain, numbness or tingling in the shoulder, arm or hand and is perhaps best known for affecting baseball pitchers and other athletes.