Blocking stress protein decreases Alzheimer’s peptide in mice

Scientists revealed in November 2006 that stress increases production in mice of a brain peptide critical to Alzheimer’s disease. Now the same group has shown that blocking a different brain peptide slows the stress-induced increase, opening a new door to treatment. Researchers from the School of Medicine report the results online this week in the Proceedings of the National Academy of Sciences.

New tools and new possibilities for healing the sick

The following text was excerpted from a speech by Washington University Chancellor Emeritus William H. Danforth, M.D. He was recognized in May with the Christopher Hobler Spirit of Hope Award from Hope Happens, an organziation supporting the Hope Center for Neurological Disorders at Washington University.

Gay named Hawes professor

W. Donald Gay, D.D.S., has been named the Christy J. and Richard S. Hawes III Professor at the School of Medicine. Chancellor Mark S. Wrighton and Larry J. Shapiro, M.D., executive vice chancellor for medical affairs and dean of the School of Medicine, made the announcement. Before their deaths, Mr. and Mrs. Hawes established the professorship in honor of and in gratitude to Gay, who directs the Division of Maxillofacial Prosthetics in the Department of Otolaryngology. Mrs. Hawes was one of Gay’s patients.

Personality changes may help detect form of dementia

A simple personality test could help doctors more quickly detect dementia with Lewy bodies, a form of dementia often confused with Alzheimer’s disease, according to a study led by researchers at the School of Medicine. Dementia with Lewy bodies is the second most common neurodegenerative cause of dementia. It shares many characteristics with both Alzheimer’s and Parkinson’s disease.

Gene discovery lays groundwork for targeted therapies for endometrial cancer

Discovery of alterations in a gene called FGFR2 could accelerate the development of new treatments for endometrial cancer, a type of uterine cancer. Researchers at Washington University School of Medicine in St. Louis; the Translational Genomics Research Institute (TGen); the Wellcome Trust Sanger Institute, which is part of Cambridge University; and New York University School of Medicine reported the findings in the May 21, 2007, online version of the journal Oncogene.

WUSTL creates center to study women’s infectious diseases

The School of Medicine is launching a new effort to study infectious diseases that preferentially affect women. The center for Women’s Infectious Disease Research (cWIDR) will focus on issues such as microorganisms that cause urinary tract infections, infections that lead to premature delivery and microorganisms that may contribute to life-threatening conditions such as cancer and heart disease.
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