Author: Ken Duenke

An enzyme researchers have studied for years because of its potential connections to cancer, diabetes, heart disease, hypertension and stroke appears to have yet another major role to play: helping create and maintain the brain. When scientists at the School of Medicine selectively disabled the enzyme AMP-activated protein kinase (AMPK) in mouse embryos, overall brain size was reduced by 50 percent, the cerebrum and cerebellum were shrunken, and the mice died within three weeks of birth.

Researchers at the School of Medicine have linked a potential indicator of Alzheimer’s disease to brain damage in humans with no signs of mental impairment. Although their cognitive and neurological assessments were normal, study participants with lower levels of a substance known as amyloid beta 42 (A-beta 42) in their cerebrospinal fluid (CSF) had reduced whole brain volumes, suggesting that Alzheimer’s changes might already be damaging their brains.

SandellLinda J. Sandell, Ph.D., has been named the Mildred B. Simon Research Professor of Orthopaedic Surgery at the School of Medicine. “Linda Sandell is a very talented scientist who has contributed a great deal to Washington University and to our understanding of the basic cellular mechanisms behind diseases of the connective tissues,” said Washington University Chancellor Mark S. Wrighton.

A $4 million Era of Hope Scholar Award has been given to Jason Weber, associate professor of medicine in the Division of Oncology at the School of Medicine. Weber will study potential new ways to control breast cancer cell growth. Surprisingly, that’s an area of research that has been relatively neglected.

Blue shows normal brain function, while other colors show overactivity due to depression.Neuroscientists at the School of Medicine have identified a key difference in the way the brain functions in people who are depressed compared to those who are not. The study demonstrates that brain regions, collectively known as the default mode network, behave differently in depressed people. The default network typically is active when the mind wanders. It shuts down when an individual focuses on the job at hand. But the researchers found the network stays active in people who are depressed, even when they are concentrating on specific tasks.

Community-based conservation in Madagascar, property rights for the poor in Argentina and trade-offs between violence and power in societies throughout human history are among topics to be explored in a free public workshop on the social science of international development from 9 a.m. to 5 p.m. March 24 in the Women’s Building Formal Lounge.

The Record will not be published next week due to spring break.

Computer science faculty are exposing their undergraduate students to learning in ways that prepare them for interaction in the real work place. It’s not about “staying between the lines,” but more about getting out of your seat, moving around and interacting with your classmates. It’s called active learning, a learning-laboratory-based tutorial teaching concept.

Janine Benyus, one of the pre-eminent practitioners of biomimicry, will speak for the Assembly Series at 5:30 p.m. March 19 in Graham Chapel.

Courtesy PhotoMen’s basketball team members celebrate with their head coach, Mark Edwards, after defeating rival University of Chicago, 72-49, Feb. 28 and helping Edwards win the 500th game of his coaching career.