Author: Ken Duenke

An immune system gene that flunked its first tryout as an antiviral factor has triumphed in its second, proving that it can help fight the flu, herpes and the Sindbis virus. Picking the right opponents for interferon stimulated gene 15 (ISG15) to square off against proved to be key to uncovering its potential.

The growth factor G-CSF caused bone tumors to increase in size in lab mice. The mouse on the left did not receive G-CSF. The mouse on the right did.In laboratory tests on mice, researchers found that a medication often used to reduce toxic side effects of chemotherapy induced bone loss and helped tumors grow in bone. So the researchers are recommending increased awareness of bone health during cancer treatments. The medication studied is a growth factor commonly used to help cancer patients recover healthy blood counts after chemotherapy, which can destroy white blood cells.

By all expectations, it shouldn’t have worked as well as it did. A combination of bone marrow transplantation and gene therapy greatly lengthened the lives of laboratory mice doomed by a rapidly progressing, fatal neurodegenerative disorder also found in people. The School of Medicine researchers who made the discovery set out with low hopes for the combination therapy because on its own, each treatment was only modestly effective for the sick mice.

In remembrance of Dr. Martin Luther King Jr., the Society of Black Student Social Workers (SBSSW) at the George Warren Brown School of Social Work will host “Financial Freedom Seminar: Achieving Economic Independence Through Education,” Jan. 20 from 8:30 a.m.- 3 p.m. in Brown Hall. This free event is designed for members of the St. Louis community interested in building wealth, maintaining good credit, purchasing a home or starting a business. The deadline to register for this event is Jan. 15. “SBSSW’s goal is to present the King Holiday, not as a tradition or a history lesson, but as a call to action- to fight for economic and social justice,” says Charletra Hurt, SBSSW co-chair and first-year student at the School of Social Work.

MuslinAnthony Muslin has been named the Oliver M. Langenberg Distinguished Professor of the Science and Practice of Medicine at Washington University School of Medicine in St. Louis. The professorship was established by the Edward Mallinckrodt Jr. Foundation in recognition of Oliver M. Langenberg’s outstanding contributions to the foundation’s success. Langenberg serves as the foundation’s chairman of the board.

Class-action lawsuits can significantly slow or halt science’s ability to establish links between neurological illness and environmental factors produced by industry, a team of scientists and lawyers warns in the journal Neurology. The authors caution that litigation’s effects could seriously impair efforts to identify compounds that contribute to a wide variety of diseases, including Parkinson’s disease, Alzheimer’s disease and amyotrophic lateral sclerosis (ALS).

Tests of a protein’s role in the immune system have revealed a surprising connection to a kidney problem that occurs in approximately one percent of all live births. This condition, known as functional obstruction, impairs the ureter’s ability to pump urine from the kidney to the bladder. If untreated, this leaves urine stuck in the kidney, which balloons and becomes at risk of failure.

A link between obesity and the microbial communities living in our guts is suggested by new research at the School of Medicine. The findings indicate that our gut microbes are biomarkers, mediators and potential therapeutic targets in the war against the worldwide obesity epidemic.

As part of Washington University’s celebration of the Danforth Campus dedication, and to underscore the important role of higher education in society, a lecture series will debut on October 3 with succeeding events on October 16 and November 13 – all being held in Graham Chapel at 4 p.m. Titled “A Higher Sense of Purpose,” its speakers will cover some of the more cogent topics being discussed today, with the goal of generating new ideas and creating a dialogue to move the conversations forward. All three programs are free and open to the public.

More than a decade of searching for factors that make the common parasite Toxoplasma gondii dangerous to humans has pinned 90 percent of the blame on just one of the parasite’s approximately 6,000 genes.